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Flumazenil, a specific benzodiazepine-receptor antagonist, is indicated for the whole or partial reversal on the sedative effects of benzodiazepines and could be used in conditions when an overdose that has a benzodiazepine is known or suspected. Before the administration of flumazenil, necessary steps should be instituted to safe airway, ventilati

Aged and very unwell sufferers can quite possibly knowledge apnea or cardiac arrest. Concomitant usage of other central anxious method depressants increases this risk. The smallest feasible productive dose should be employed for this group of men and women.[fifty nine][sixty] The aged metabolise benzodiazepines a great deal more slowly but surely t